Top 10 Best Hypoallergenic Pillow Covers [2025]

NoProductScoreAction
1Set of 2 Standard Size SureGuard Pillow Protectors - 100% Waterproof9.8Buy On Amazon
2Aller-Ease Hot Water Washable Hypoallergenic Zippered Pillow Protectors9.8Buy On Amazon
3Four Seasons Essentials Standard Pillow Protectors (Set of 2) – Zippered Waterproof Pillow Covers Hypoallergenic Dust Proof Pillowcase Encasement Cover9.6Buy On Amazon
4AllerEase Ultimate Pillow Protector9.4Buy On Amazon
5Aller-Ease Cotton Pillow Protectors9.2Buy On Amazon
6Everlasting Comfort Waterproof Pillow Protectors - Set of 29.2Buy On Amazon
7baceight 18x18 Pillow Covers Set of 4 Decorative Cozy Hypoallergenic Throw Pillow Covers Pattern Square Farmhouse Pillow Covers Throw Pillow Shams for Sofa Bedroom Car9Buy On Amazon
8AllerEase Maximum Allergy Pillow Protector8.6Buy On Amazon
9Amazon Basics 100% Cotton Hypoallergenic Pillow Protector Case - Standard8.4Buy On Amazon
10Guardmax Waterproof Pillow Protectors - Zippered Pillow Covers Bed Bug Hypoallergenic Pillow Cases8.2Buy On Amazon
Disclaimer: As An Amazon Associate I Earn From Qualifying Purchases.

1. Set of 2 Standard Size SureGuard Pillow Protectors – 100% Waterproof

  • 100% Waterproof – Total protection against perspiration, saliva, liquids and stains; 10-year quality guarantee.
  • Bed Bug Proof – Super fine zipper with Invisi-Zip technology completely seals off your pillow from bed bugs – Best used with SureGuard Mattress and Box Spring Encasements.
  • Hypoallergenic – Keep Your Pillows Clean & Fresh – Blocks dust mites, mold, mildew, pollen and pet dander.
  • Soft & Noiseless – Smooth 100% cotton surface; Wicks away moisture; Retains the feel of your pillow – Free from Vinyl, PVC, Phthalates, fire retardants and other toxic chemicals.
  • Standard Size (21 in x 27 in) Zippered Pillow Case Covers – Set of 2 – Machine wash & dry.

2. Aller-Ease Hot Water Washable Hypoallergenic Zippered Pillow Protectors

  • ADVANCED ALLERGY PROTECTION: AllerEase protectors offer complete barrier protection from pet dander and dust collecting in your pillow.
  • EXTEND PILLOW LIFE: Fully encasing your pillow with a durable and comfortable zippered protector extends the life of your pillow by keeping it fresh and clean.
  • BREATHABLE – Breathes naturally and doesn’t trap body heat or moisture unlike vinyl or plastic covers.
  • HOT WATER WASHABLE – These pillow covers are able to be washed in hot water giving you a fresh and clean feeling.

3. Four Seasons Essentials Standard Pillow Protectors (Set of 2) – Zippered Waterproof Pillow Covers Hypoallergenic Dust Proof Pillowcase Encasement Cover

  • Set includes 2 Standard Size Pillow Protectors measuring 21″ (Width) x 27″ (Length).
  • WATERPROOF – Whether you have pets or kids, accidents and spills happen.
  • SOFT & NOISELESS – Stretchable, breathable fabric keeps liquids, contaminants out without compromising comfort.
  • HYPOALLERGENIC – Impenetrable cover helps you breathe easy.
  • ZIPPERED PROTECTOR – Zipper closure completely seals off the pillow! Made of high quality polyester (top surface) and waterproof polyurethane (inside lining).

4. AllerEase Ultimate Pillow Protector

  • ADVANCED ALLERGY PROTECTION: AllerEase pillow protectors have tightly woven, expertly-designed fabric to prevent unhealthy household particles from collecting in your pillow.
  • EXTEND PILLOW LIFE: Fully encasing your pillow with a durable and comfortable zippered protector extends the life of your pillow by keeping it fresh and clean.
  • TEMPERATURE BALANCING: Commonly used in high-performance athletic clothing, our fabric technology retains heat when you’re cold and releases heat when you’re hot to deliver continuous comfort.
  • QUIET NIGHT: With a soft, quiet cover AllerEase pillow protectors help you sleep comfortably through the night.
  • ALLERGIST RECOMMENDED: All AllerEase products provide clean allergy relief, are machine washable, and have a Lifetime limited warranty.

5. Aller-Ease Cotton Pillow Protectors

  • ADVANCED ALLERGY PROTECTION: AllerEase pillow protectors have tightly woven, expertly-designed fabric to prevent unhealthy household particles from collecting in your pillow.
  • EXTEND PILLOW LIFE: Fully encasing your pillow with a durable and comfortable zippered protector extends the life of your pillow by keeping it fresh and clean.
  • BREATHABLE COTTON: Made of 100% breathable cotton, these allergy barrier protection pillow covers are soft to the touch, easy to care for and do not retain heat, so you can get a cool, comfortable and allergy-free night’s sleep!.
  • QUIET NIGHT: With a soft, quiet cover AllerEase pillow protectors help you sleep comfortably through the night.

6. Everlasting Comfort Waterproof Pillow Protectors – Set of 2

  • Ruined Pillows Are a Thing of the Past: Our pillow case protectors are 100 percent waterproof, shielding against bodily fluids, sweat, and other liquid threats.
  • Our Full Encasement Pillow Covers Protect Like Regular Covers Can’t: Normal covers are open ended, allowing irritants in, while our pillow protectors with zipper keep all sides of your pillows fully encased for better protection.
  • Goodbye Sneezing, Hello Better Sleep: Our hypoallergenic pillow cover is resistant to common irritants, prevents feathers in down pillows from poking through, so you can stop sneezing and start sleeping better.
  • Breathable Waterproof Pillow Covers Keep You Comfy and Cool: Designed with a unique protective membrane that allows for good airflow while keeping moisture out.
  • Lifetime Replacement Policy: At Everlasting Comfort we take your experience with our products to heart.

7. baceight 18×18 Pillow Covers Set of 4 Decorative Cozy Hypoallergenic Throw Pillow Covers Pattern Square Farmhouse Pillow Covers Throw Pillow Shams for Sofa Bedroom Car

  • PREMIUM HIGH-QUALITY MATERIAL】:This pillow covers is made of microfiber plush, it is soft, comfortable, skin-friendly for kids and pets.
  • AVAILABLE SIZE】:Our throw pillow covers measures 18″ x 18″ / 45cm x 45cm (It might has the deviation range 1-2cm) , the pillow covers not included the insert, also available in 16″ x 16″, 20″ x 20″.
  • IDEAL DECORATION FOR YOUR HOME】:The set of 4 pillow covers with hidden zipper closure is easy to match your sofa, couch, bed, office, patio, porch, Perfect addtion for your all year around decorations.
  • CARE INSTRUCTIONS】:Machine Wash Cold Separately, Gently Cycle Only, No Bleach, Tumble Dry Low, Do Not Iron, Low Temperature if Necessary.
  • NO RISK PURCHASE】: Don’t forget that your satisfaction is our #1 priority.

8. AllerEase Maximum Allergy Pillow Protector

  • MAXIMUM ALLERGEN PROTECTION – Aller-Ease Maximum Allergy and Bedbug Zippered Pillow Protectors provide protection from dust mites, pet dander, pollen and other household allergens that can trigger allergy and asthma symptoms.
  • BREATHABLE FABRIC – Made of breathable fabric that won’t alter the feel of your pillow, these allergy protection pillowcases are soft to the touch.
  • BEDBUG PROOF – Fully encasing your pillow in this zippered hypoallergenic case provides a secure barrier against bedbug entry so you can confidently rest your head and relax.
  • MACHINE WASHABLE – This allergy pillow cover set is easy to care for so you can renew and refresh your bedding for a consistently clean night’s sleep.

9. Amazon Basics 100% Cotton Hypoallergenic Pillow Protector Case – Standard

  • 100% cotton, vinyl-free hypoallergenic pillow protector is designed with a tight weave to minimize exposure to dust and other common allergens while providing breathable, cool comfort.
  • Zipper closure fully encloses the pillow and creates a clean tailored look.
  • Machine wash and tumble dry on low heat; do not dry-clean.
  • One 21 by 27 inch pillowcase; suitable for standard size pillows.
  • Made in Green by OEKO-TEX, an independent certification system that ensures textiles meet high safety and environmental standards.

10. Guardmax Waterproof Pillow Protectors – Zippered Pillow Covers Bed Bug Hypoallergenic Pillow Cases

  • Zippered PROOF – Rest peacefully knowing that bedbugs won’t be bugging you tonight! Our super fine zipper will keep bedbugs out completely.
  • 100% WATERPROOF on Top, Sides & Bottom – Our protectors seal out moisture, liquid, saliva, sweat and anything wet! A GREAT IDEA for people with children or grandchildren who spend the night.
  • Healthy AND HEALTHY – Protect yourself and your family against particles s, debris and .
  • QUIET & RESTFUL NIGHTS –You won’t experience any crinkling, cracking, or annoying sounds like most waterproof cases.
  • EASY WASH & CARE – Our protectors can easily be machine washed and dried.